Publications

Research Highlights

Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up
This publication features key outcome data from the PREFECT study demonstrating MyoStrain's ability to help clinicians detect and predict early cardiotoxicity in patients undergoing cancer therapy. These findings highlight MyoStrain as an accurate and sensitive assessment that may enable cardio-oncologists to implement cardio-protective strategies for cancer patients.
Circulation: Cardiovascular Imaging
June 15, 2021
Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR: Diagnostic Accuracy of a Needle-Free Stress Protocol
This article demonstrates MyoStrain’s speed and sensitivity to successfully measure cardiac stress during a safe, simple hyperventilation breathing maneuver. Performed without any pharmacological or physical stress protocols, this new technique may provide clinicians with a faster and safer quantitative stress test to help improve the diagnosis and management of coronary artery disease.
JACC: Cardiovascular Imaging
April 15, 2021
Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis
The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.
Journal of Cardiovascular Magnetic Resonance
April 5, 2021
Fast strain-encoded cardiac magnetic resonance for diagnostic classification and risk stratification of heart failure patients
This article demonstrates MyoStrain's ability to identify patients with subclinical LV dysfunction and those at risk for heart failure-related outcomes compared with LVEF, providing an additional diagnostic window for prevention treatments.
JACC Cardiovascular Imaging
January 13, 2021
Economic evaluation of cardiac magnetic resonance with fast-SENC in the diagnosis and management of early heart failure
A cost-impact analysis of MyoStrain in the early diagnosis and management of MyoStrain, this manuscript compares the cost-saving potential of MyoStrain versus echocardiography.
BMC Health Economics Review
May 23, 2019
Strain‐encoded magnetic resonance: a method for the assessment of myocardial deformation
This clinical review article describes the history and evolution of the MyoStrain technology. The manuscript itself provides a detailed summary of existing literature about MyoStrain and its predecessor technologies HARP and SENC, totaling 400+ publications representing 70,000+ patient data points to date.
ESC Heart Failure Journal
April 25, 2019
Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up
This publication features key outcome data from the PREFECT study demonstrating MyoStrain's ability to help clinicians detect and predict early cardiotoxicity in patients undergoing cancer therapy. These findings highlight MyoStrain as an accurate and sensitive assessment that may enable cardio-oncologists to implement cardio-protective strategies for cancer patients.
Circulation: Cardiovascular Imaging
June 15, 2021
Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR: Diagnostic Accuracy of a Needle-Free Stress Protocol
This article demonstrates MyoStrain’s speed and sensitivity to successfully measure cardiac stress during a safe, simple hyperventilation breathing maneuver. Performed without any pharmacological or physical stress protocols, this new technique may provide clinicians with a faster and safer quantitative stress test to help improve the diagnosis and management of coronary artery disease.
JACC: Cardiovascular Imaging
April 15, 2021
Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis
The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.
Journal of Cardiovascular Magnetic Resonance
April 5, 2021

Select MyoStrain® Publications

The MyoStrain technology is rigorously validated across 500+ peer-reviewed publications (including 50+ in JACC and Circulation) representing more than 80,000 patient data points. The following selection contains the most recent and pivotal articles not highlighted above.

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Layer-specific strain-encoded MRI for the evaluation of left ventricular function and infarct transmurality in patients with chronic coronary artery disease
This study evaluates the use of MyoStrain (SENC) for quantifying segmental myocardial strain to help determine LV heart function in patients with chronic coronary artery disease (CAD).
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Stress Testing
November 8, 2011
International Journal of Cardiology
Strain-Encoded Cardiac Magnetic Resonance During High-Dose Dobutamine Stress Testing for the Estimation of Cardiac Outcomes
This paper demonstrates MyoStrain's clinical utility in the rapid assessment and quantification of ischemia to help guide clinical decision-making for chest pain patients entering the ER.
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Stress Testing
September 6, 2011
JACC Cardiovascular Imaging
Identification and further differentiation of subendocardial and transmural myocardial infarction by fast strain-encoded (SENC) magnetic resonance imaging at 3.0 Tesla
Authors use circumferential and longitundal strain acquired from MyoStrain rapid strain-encoding (fast-SENC) to measure and identify old myocardial infarction as well as differentiate subendocardial from transmural infarction.
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Heart Failure
June 18, 2011
European Journal of Radiology
Prevalence and distribution of regional scar in dysfunctional myocardial segments in Duchenne muscular dystrophy
This article demonstrates the reproducibility, efficacy, and broad clinical applications of MyoStrain predecessor HARP by utilizing HARP's tagging-based strain to detect subclinical cardiac dysfunction in Duchenne muscular dystrophy (DMD), as compared against ECHO-derived global strain.
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March 11, 2011
Journal of Cardiovascular Magnetic Resonance
Myocardial delayed enhancement in pulmonary hypertension: pulmonary hemodynamics, right ventricular function, and remodeling
This paper demonstrates the clinical utility of MyoStrain segmental myocardial strain analysis to detect right ventricular dysfunction in patients with pulmonary hypertension.
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Chronic Diseases
January 1, 2011
American Journal of Roentgenology
Real-time single-heartbeat fast strain-encoded imaging of right ventricular regional function: normal versus chronic pulmonary hypertension
In this paper, MyoStrain (fast-SENC) is evaluated for its rapid, real-time assessment of right ventricular function in patients with normal and chronic pulmonary hypertension using segmental myocardial strain.
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Chronic Diseases
June 22, 2010
Magnetic Resonance in Medicine
Strain-Encoded CMR for the Detection of Inducible Ischemia During Intermediate Stress
This paper utilizes MyoStrain's non-invasive stress test technique to identify subtle changes in heart function indicative of ischemia in patients suspected of coronary artery disease.
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Stress Testing
April 1, 2010
JACC: Cardiovascular Imaging
Circumferential Strain Analysis Identifies Strata of Cardiomyopathy in Duchenne Muscular Dystrophy A Cardiac Magnetic Resonance Tagging Study
This article demonstrates the reproducibility, efficacy and broad clinical applications of MyoStrain predecessor HARP by occult cardiac dysfunction in Duchenne muscular dystrophy (DMD), as compared against left ventricular ejection fraction (LVEF).
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Chronic Diseases
April 1, 2009
Journal of American College of Cardiology
Strain-encoded MRI for evaluation of left ventricular function and transmurality in acute myocardial infarction
This article shows MyoStrain's ability to directly quantify segmental heart function using MyoStrain's SENC MRI pulse sequence, treatment scale and post-processing analysis of dysfunction in acute myocardial infarction (AMI) patients.
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Heart Failure
January 26, 2009
Circulation Cardiovascular Imaging