Stress Testing — Needle Free Ischemia Detection

Quantitative Precision for Coronary Artery Disease

Up to 20% of traditional stress tests produce false positives or false negatives leading to unnecessary procedures, delayed diagnosis, or missed ischemia.

MyoStress® is a rapid, and non-invasive breathing maneuver (BPV) stress test that quantifies how the heart responds to increased oxygen demand, helping clinicians detect myocardial ischemia and assess coronary artery disease (CAD) in 15 minutes, without pharmacologic stressors, contrast agents, or radiation exposure.

This allows physicians to visualize:

  • Ischemic regions that fail to increase contraction during stress for guided individualized intervention.
  • Viable, hibernating myocardium that recovers with medical therapy and
  • Contractile reserve with improved MyoHealth® Score in non ischemic patients

Transforming Chest Pain Triage

Chest pain is one of the most common reasons people visit the emergency room, but finding out exactly what is causing it can be hard. Doctors often must run several tests one after another, which takes time and can still leave the cause unclear.  

MyoStress® may change this by using a simple, needle-free breathing exercise that takes about 15 minutes. It helps doctors decide if a patient is having an immediate heart condition, send home patients whose chest pain is not from the heart, or direct patients with other heart problems to the right follow-up care. 

  1. Santos Argueta AE, et al. Multivessel Coronary Artery Disease Presenting as a False-Negative Nuclear Stress Test. Cureus. 2024. PMC10923640 — directly states the 10–20% false negative figure for MPI. 
  2. Ochs MM, Kajzar I, Salatzki J, Ochs AT, Riffel J, Osman N, Katus HA, Friedrich MG. Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR: Diagnostic Accuracy of a Needle-Free Stress Protocol. JACC: Cardiovascular Imaging. 2021;14(10):1932–1944.
Cardio-oncology Publications

January 11, 2024

Cardiac magnetic resonance (CMR) is the gold standard for the diagnostic classification and risk stratification in most patients with cardiac disorders. The aim of the present study was to investigate the ability of Strain-encoded MR (SENC) for the prediction of major adverse cardiovascular events (MACE).

January 1, 2024

This study investigated the use of layer-specific fast strain-encoded cardiac magnetic resonance imaging (fSENC) for diagnosing and prognosticating acute myocardial injury in emergency department patients.

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November 16, 2023

JACC Cardiovascular Imgaging

Several studies show a low (1-3%) but real risk of myocarditis in competitive athletes after SARS-CoV-2 infection.

Stress testing publications